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Importantly, SARS-CoV-2 can enter and infect endothelial cells via the ACE2 receptor 150 , with viral replication causing inflammatory cell infiltration, endothelial cell apoptosis and microvascular prothrombotic effects 151

Typical Protocol: Commonly cited protocols use 1.5-1.6 mg subcutaneously two to three times per week (mirroring the Zadaxin regimen used in hepatitis trials), often run in 4 to 16 week cycles for general wellness use, with the original clinical trials using 1.6 mg twice weekly for 6 to 12 months

Not surprisingly, some of the pharmacokinetic parameters obtained from this study differed from those obtained by Larson, et al .[51] In the current study, the median C max was 1.47 ng/ml, with the highest rapamycin blood concentration measured being 2.13 ng/ml

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They highlight the need for vigilance regarding potential side effects, the importance of considering individual patient histories and susceptibilities, and the necessity of holistic care approaches that address both the physical and emotional aspects of treatment