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This creates a vicious cycle: viral inflammation depletes antioxidants, genetic bottlenecks prevent the synthesis of new antioxidants, and the resulting oxidative stress causes the mitochondria to shut down ATP production, leading to the debilitating fatigue that characterizes ME/CFS and Long COVID
Most studies involving CoQ10 report few to no adverse effects in study populations.3 When side effects did occur, they were generally mild and included: CoQ10 appears to be safe at doses as high as 720mg/day.3 According to the NIH, CoQ10 should be avoided if youre taking chemotherapy drugs, as the data for potential contraindications is too limited
Chemical structures of vitamin E isoforms The figure shows the chemical structures of vitamin E isoforms in two panels: Panel A: Natural -tocopherol, produced by plants, has an RRR -configuration at the 2, 4, and 8 of the molecule
The Master Antioxidant Glutathione (GSH) Shungus findings suggest that high levels of reactive oxygen species (ROS) and low levels of antioxidants (glutathione) are part of the neuroinflammatory mix in the brain in ME/CFS
International Journal of Obesity
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