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Because B12 is water soluble, your body does not store it, so it needs to be replenished on a consistent basis
Tainaka H et al
In metabolically active tissues, fatty-acid handling may involve CD36, plasma-membrane fatty-acid-binding protein, and fatty-acid transport proteins, although their relative contribution depends on tissue and physiological state
If you do the math, that's an 8% concentration firmly in the advanced range
If your levels were already healthy, a single shot tops you off, and the noticeable effects fade sooner
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