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Animal studies show that GLP-1 receptor activation in the hypothalamus changes core body temperature set-points by small amounts, which can produce mild sweating events as the body re-regulates

11 Apr 2026 Safer Antihyperglycaemic Agents Identified for Older Adults In this large cohort study spanning nine databases across the USA and Europe, researchers compared 18 safety outcomes across four major classes of second-line antihyperglycaemic agents

Nat Rev Neurosci 17 , 576591 (2016)

If you have severe gastrointestinal side effects, if you have excess lethargy, if you experience vision problems, or if you have any other signs of a serious problem, your doctor will generally order a repeat blood test, while also advising you to stop taking semaglutide

For instance, drugs that cause urinary retention or reduce bladder emptying can increase UTI risk by allowing bacteria to multiply in the urinary tract