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Additionally, tirzepatide was linked to more pronounced weight loss compared to semaglutide

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For some individuals, metabolic or bariatric surgery, such as gastric sleeve, gastric bypass or endoscopic sleeve procedures, may be appropriate

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NICE does not currently recommend either supplement for weight management, and they are not part of standard NHS obesity treatment pathways, which emphasise lifestyle modification, behavioural support, and where appropriate, licensed medications such as orlistat or semaglutide (Wegovy) within specialist services according to NICE guidance