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These side effects could also lead to weight loss
If your genetics suggest reduced GIPR function but strong MC4R regulation, a combination approach like GLP-Squared (semaglutide plus tirzepatide) could unlock better outcomes
The primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which means insulin is released only when blood glucose levels are elevated Suppressing glucagon release from pancreatic alpha cells, thereby reducing hepatic glucose production Slowing gastric emptying , which delays the rate at which food leaves the stomach and enters the small intestine Reducing appetite through central nervous system effects, promoting satiety and decreasing food intake The slowing of gastric emptying is particularly relevant when considering gastrointestinal side effects
Public Health (2019)
Katsumata et al
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