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Funding This work is supported in part by the National Institute of Neurological Disorders and Stroke/National Institutes of Health grants R01NS095825 (to CG)
Concentrations decline sharply with age: plasma levels drop from roughly 200 ng/mL at age 20 to under 80 ng/mL by age 60
However, DIO mice switched from an obesity-promoting WD to an LD (regardless of treatment status) displayed several genera and phyla differences compared to obese and lean controls
doi: 10.1056/NEJMe2307285
Sterile Practices for Injections: If injectable forms are used, strict adherence to sterile practices (e.g., using new sterile needles for each injection, cleaning vial tops and injection sites with alcohol, rotating injection sites) is crucial to minimize the risk of localized infections and tissue irritation
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