Safety and tolerability were assessed through reported adverse events (AEs), hypoglycaemic episodes (defined as confirmed if the episode was severe according to the American Diabetes Association [ADA], i.e
Weight management can be a very demanding, often tedious process
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Side effects included nausea (39% of patients), diarrhea (25%) and vomiting (28%) [29] Overall, orfoglipron achieves comparable weight loss with other GLP1R agonists such as semaglutide and Rybelsus, but has a slightly better side effect profile and achieves weight loss in a shorter period of time