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Retrieved from Davies, M., Frch, L., Jeppesen, O
f , Averaged Z-score traces showing dopamine release in the NAc in response to HFD following administration of vehicle or danuglipron in WT mice
4 Other than being on GLP-1s, higher risk patients include: those in the dose-escalation phase and those with upper GI symptoms (eg, nausea, vomiting, dyspepsia, abdominal distension, and abdominal discomfort/pain). 4 And obviously, other high-risk group includes patients with comorbidities associated with delayed gastric emptying (eg, poorly controlled diabetes, Parkinsons disease, bowel dysmotility) as well as those on other drugs that slow gastric emptying (eg, opioids, tricyclic antidepressants, marijuana, alcohol)
To determine whether a less-pronounced elevation of FBP elicits a similar phenotype, we reduced the duration of our knockdown protocol to one round of siRNA transfection
Notably, in most countries PAC is freely sold as an OTC drug, raising the risk of unintentional abuse and increased adverse effects (Sansgiry et al., 2017)
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