How Tirzepatide and Semaglutide Affect the Body in Different Ways Tirzepatide and semaglutide work on appetite, hormones, and blood sugar control, but they interact with the brain and gut differently
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A useful benchmark: if you have lost 20 percent or more of starting body weight, if your appetite is well-controlled, and if you are tolerating the current dose without significant GI burden, there is no clinical imperative to escalate further