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Once inside the cell, the complex interacts with intracellular copper-responsive pathways which is what enables the downstream gene-modulation effects to translate from topical application into measurable dermal changes

A detailed medical history helps identify hormonal, nutritional, or medication-related factors

The level of selenite in tendons is unknown, and the activity of GPX in chondrocytes reportedly increases by adding sodium selenite (50 nM) for 24 h (Yan et al., 2013)