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When people lose significant weight through calorie restriction alone, metabolic adaptation kicks in, reducing resting energy expenditure by 15 to 20 percent more than would be predicted by the change in body mass alone

doi: 10.1016/0720-048x(90)90163-6 25 BuhlRBarthHHugoHHMautnerVFMehdornHM

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Top panel: The ratio of oxidized and reduced glutathione ratio were reduced by 18-20% in the high-dose group (striped bars) at weeks 1 and 2