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Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRAS(G12C), are associated with renal toxicity in the Sprague Dawley rat

Serban MC, Sahebkar A, Zanchetti A, Mikhailidis DP, Howard G, Antal D, et al

These data align with previous work 33 that also demonstrated that central administration of a GIPR antagonist antibody (Gipg013) has anti-obesity effects in DIO mice and leads to decreased hypothalamic expression of suppressor of cytokine signalling 3 ( Socs3 ), an inhibitor of leptin

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