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To evaluate the functional relevance of the GLP-1R cholesterol binding sites identified during the cgMD simulations, 12 residues were selected within or at the periphery of these sites and mutated to alanine by site-directed mutagenesis (Figure 2F)

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Kate Hanna (CAN), +1 905 301 7334, [email protected] SOURCE Novo Nordisk Canada Inc.

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