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I was working to answer physiology questions like how does diabetes affect the heart and how does diabetes affect muscle glucose uptake
For example, after GLP-1 binding the transmembrane helices 1 (TM1) rotates clockwise when looking down the membrane helices from the extracellular face (see TM1 marked in Figure 6) and a kink is introduced in the transmembrane helix 6 (TM6), as is typical for all class B1 GPCRs
( Study by Diebold S, et al
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