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Plovier et al

By controlling weight gain and improving lipid profiles, acetate lowers obesity-induced cardiac injury risk (Wang et al., 2022)

However, current American Diabetes Association (ADA) and American College of Cardiology/American Heart Association (ACC/AHA) guidelines no longer routinely recommend niacin for cardiovascular risk reduction due to lack of demonstrated outcome benefits and potential adverse effects

In liver mitochondria, cholesterol accumulation has been found to disrupt mitochondrial functional performance which can contribute to oxidative stress and organ injury 60

Belal MM, Proceedings (Baylor University Medical Center) (Vol