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Broad Institute Connectivity Map analysis shows it influences approximately 6% of the human genome making this one of the most broadly active signaling peptides in published research

Some GPX4 immunoreactivity was associated with the dystrophic axons in PD putamen (Figure 5D, lower right), in contrast with the lack of GPX4 found in TH-positive terminals in non-PD subjects

Lie et al., 2002)

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