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Heart rate monitoring may be warranted given the glucagon component mild chronotropic effects

It combines the effects of GLP-1 agonism with those of GIP, potentially offering additional benefits: - Enhanced insulin secretion and sensitivity - Greater appetite suppression - Improved lipid metabolism - Potential direct effects on adipose tissue[1] This dual action may explain why tirzepatide has shown superior efficacy in clinical trials, demonstrating greater reductions in HbA1c levels and body weight compared to existing therapies, including semaglutide[4]

Of course, side effects like nausea or digestive changes may (naturally) make intimacy less appealing at times

Most people find they need minimal changes

Several users report vivid dreams that wake them and make it harder to fall back asleep