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The emergence of dysesthesia as a notable side effect is unique to retatrutide in this comparison
GLP-1 Medications and Mental Health: Separating Fact from Fiction Key Points GLP-1 medications do not increase risk of depression, anxiety, or suicidality compared to placebo These medications modestly improve mental health-related quality of life independent of weight loss Emotional eating and food cravings significantly decrease with GLP-1 treatment Psychiatrists should proactively prevent weight gain from psychiatric medications, not just accept it as inevitable GLP-1s may be particularly useful for antipsychotic-induced weight gain, similar to how we already use metformin Side effects are mostly gastrointestinal and manageable with proper dosing and titration Theres been a lot of noise about GLP-1 medications and mental health
The inclusion of gentle exercise as part of a regular daily and weekly routine also helps us replenish our natural GSH production
Expert discovery is scheduled to be completed by March 27, 2026, with motions for summary judgment due April 16, 2026, followed by preparations for the first bellwether trials
