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doi:10.1016/S2213-8587(20)30271-0 10

Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds

When we need energy in a high amount due to increased metabolic demand, such as while doing high-intensity exercise, this stored muscle creatine content in the form of creatine phosphate is converted to ATP, generating a burst of energy we require during these strenuous conditions

Such heterogeneity may complicate cross-ancestry PRS performance and underscores the need for ancestry-diverse training datasets to improve calibration and reduce disparities in genetic risk prediction