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Human Microbiome Journal

You should contact your GP or healthcare provider if you experience: Persistent extreme cold intolerance that significantly affects your daily activities or quality of life Cold sensitivity accompanied by other symptoms of hypothyroidism , such as unexplained weight gain (despite continued Wegovy use), severe fatigue, constipation, dry skin, hair loss, or depression Shivering or inability to warm up even in heated environments Changes in heart rate, particularly a notably slow pulse (bradycardia) Swelling in the neck or difficulty swallowing Any new or worsening symptoms that concern you Your GP may wish to perform thyroid function tests (typically measuring TSH and possibly free T4) to rule out hypothyroidism if symptoms suggest this condition

Fluid retention or swelling in the legs, feet or ankles

Punctured vials during travel: Vials in active multi-dose use require the same storage discipline during travel as at home: temperature control, light protection, and aseptic technique on every draw

How Does Tirzepatide Aid in Weight Loss and Appetite Control