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The use of H.pylori eradication therapy or combined use of nizatidine with either vitamin E, thioctic acid or a combination of both resulted in remarkably higher ulcer healing rates in duodenal ulcer patients (100, 86.67, 73.34, 93.34%) compared to the regular use of nizatidine alone (60%)
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However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC
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