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Curated affinity data instead describe a full agonist at four of the five human melanocortin receptors: reported pIC 10.0 at MC1R, pKi 8.9 at MC3R, pKi 8.5 to 8.8 at MC4R, and pIC 9.0 at MC5R, with no activity at MC2R, the adrenocorticotropin receptor, which is not engaged by alpha-MSH analogues of this class

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PubMed laboratory research record [PMID: 32932644] PubMed record related to this compound for laboratory literature review

Tirzepatide targets two gut hormones rather than one, and the clinical trial data reflects that difference