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[24] Deficiency Vitamin B 12 deficiency can potentially cause severe and irreversible damage, especially to the brain and nervous system

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Benefits: Longer duration of action compared to cyanocobalamin May require less frequent dosing Preferred for patients with certain medical conditions Population-Specific Formulation Preferences The choice between cyanocobalamin and hydroxocobalamin depends on individual patient needs

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Conservative protocols involving cycling address this uncertainty by limiting continuous exposure