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The use of nalbuphine, a blocker of - and -opioid receptors, also disrupted the effect of GLP-1RAs on reducing TNF- levels, highlighting the essential role of these opioid receptors in the anti-inflammatory effects mediated by GLP-1RAs

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Importantly, IGF-1 LR3 treatment reduced circulating amino acids, notably branched-chain amino acids, which have been shown to potentiate GSIS and protein accretion supporting fetal growth

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