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On the contrary, the positive effect of GIP on glucagon secretion is preserved [34]
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In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)
Beyond its insulinotropic effects, GLP-1R signaling also influences lipid metabolism by modulating hepatic lipid handling and adipose tissue function
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