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Research focuses on how GHK-Cu upregulates the gene expression of collagen type I, collagen type III, elastin, and proteoglycans within dermal fibroblasts, promoting structural tissue density and resilience

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25,26 This was primarily because the CEA was undertaken shortly after the products market launch, before real-world treatment patterns could be estimated, and because retreatment had not been investigated in clinical trials, leaving the effect of reinitiation uncertain

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