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The gradual increase helps minimize potential gastrointestinal side effects and allows the body to adjust to the medication

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When GLP-1s Are Not Appropriate Some situations are absolute contraindications: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN2) Pregnancy or breastfeeding , or actively trying to conceive Known hypersensitivity to the medication Others require a careful risk-benefit conversation rather than an automatic no: a history of pancreatitis, gastroparesis or significant GI disease, active gallbladder disease, advanced kidney disease, type 1 diabetes, proliferative diabetic retinopathy, or a history of eating disorders