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Less frequent AEs like hypoglycemia, is mostly seen in combination with insulin or sulfonylureas (157) and some reports of pancreatobiliary complications are partially explained by direct altered absorption of bile acids, rapid weight loss or changes in the gallbladder motility with increased risk of pancreatitis, even though it is extremely rare (160)
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While marine-derived EPA and DHA are directly bioavailable, plant-based ALA requires enzymatic conversion to its active forms
-HB elevates BDNF protein levels by increasing mitochondrial respiration and inhibiting HDACs, thereby activating promoter IV of the BDNF gene
As a result, this provides a steady supply to the bloodstream over several hours
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