Its unique chemical makeup is what allows it to slip through cell membranes and interact directly with the NNMT enzyme
However, if youre already getting enough vitamin B12 in your diet and dont have a nutrient deficiency, its unclear whether increasing your intake of vitamin B12 will have much of an effect on weight loss.
According to one large study in 9,075 people, having higher blood levels of vitamin B12 was associated with a lower risk of obesity ( Similarly, another study in 976 people showed that having low levels of vitamin B12 was linked to a higher risk of overweight or obesity ( Whats more, a study in 256 children showed that children with lower levels of vitamin B12 tended to have a higher body mass index (BMI), which is a measure of body size determined by height and weight ( However, keep in mind that while these studies show an association between vitamin B12 status and body weight, they dont take other potentially contributing factors into account
Thats more than 4 million times the recommended daily dose, and still you cant overdose
Large-scale, well-designed trials with proper randomization and blinding are needed to determine whether high-dose oral supplementation is as effective as intramuscular injection for increasing vitamin B 12 status and alleviating clinical symptoms of vitamin B 12 deficiency