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Individuals 60 years and older have lower plasma GSH levels and increased oxidative stress (Samiec et al., 1998)

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The ecto-enzymes CD39 and CD73, expressed on Tregs, catalyze the metabolism of ATP (Adenosine triphosphate) into AMP (Adenosine monophosphate) and in turn, produce the immunoregulatory purine, adenosine ( in vivo ( 3) Induction of apoptosis

This is typically modest (3-5 beats per minute) and does not require intervention unless accompanied by symptoms like palpitations or chest discomfort

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