is tirzepatide worth it weight loss trial pros and cons for A 72-week compared the two leading GLP December Blog Post: Tirzepatide, – How Does Tirzepatide Work for

What is Wegovy

Under-Dilution: Leads to a higher concentration, making precise dosing difficult

Weight loss continued as calorie intake remained lower Participants taking semaglutide achieved significant weight loss over the course of the study, with an average loss of 15.1 percent of initial body weight after 60 weeks of treatment

High-Dose Outcomes: A notable portion of participants achieved weight loss above 30%, a benchmark historically associated with surgical interventions

45.3% of participants on the highest dose lost 30% or more of their body weight TRIUMPH-4 knee osteoarthritis + obesity (Dec 2025) 28.7% weight loss at 68 weeks TRANSCEND-T2D-1 type 2 diabetes (Mar 19, 2026) A1C -2.0%, 16.8% weight loss at 40 weeks TRIUMPH-2 obesity with type 2 diabetes, nested OSA protocol (July 23, 2026) 20.8% weight loss at 12 mg over 80 weeks