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Rina Su, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Therefore, more recent research has shifted the focus to screening a drug that targets the lipotoxicity of individuals with fewer side effects to prevent and treat KOA [10, 11]

This altered hedonic response could reflect changes in gustatory processing or central integration of taste and reward signals