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While more studies are needed, current evidence supports their potential to reduce CV risk through multiple direct and indirect mechanisms, offering hope for improved outcomes in a population with historically elevated premature mortality

for instance, PMN-MDSCs predominantly utilize reactive oxygen species (ROS), whereas M-MDSCs rely more heavily on the production of nitric oxide (NO) and immunosuppressive cytokines

Reserve purely systemic injection for situations where local access is difficult or when addressing multiple widespread issues

Bupropion: pharmacology and therapeutic applications

M., Heymsfield, S