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This dynamic has played out with semaglutide already, where compounded semaglutide remains popular despite approved versions being available

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Ye Y, Xu J, Shen H, Yu Z, Chen G

Figure 7 An increase in aspartate but a decrease in glutamate and glutamine contents and synthesis has been observed in brain cortex from 17-day-old succinic-semialdehyde dehydrogenase-deficient mice together with a pronounced decrease (40%) in glutamine synthetase expression, whereas GABA production was virtually unaffected (Chowdhury et al., 2007b)

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