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NICE recommends semaglutide for weight management in eligible adults through specialist weight management services (TA875)

Researchers note that further studies would help more definitively determine overall safety for breastfeeding patients and their babies, which aligns with the overall consensus over semaglutide and other glucagon-like peptide-1 (GLP-1) receptor agonists, which are not currently advised for use during pregnancy or while nursing

Importantly, patients should not stop or adjust their Ozempic dose without consulting their diabetes healthcare team, as this could lead to loss of glycaemic control

This rebound effect often occurs due to the body's physiological responses returning to pre-treatment levels

48 As an add-on to insulin with or without metformin (PIONEER 8), oral semaglutide (at doses of 3, 7 and 14 mg) was shown to be associated with superior HbA1c and body weight reductions versus placebo as early as at week 26 and achieved further reduction in insulin need (except dose 3 mg) at week 52, without significantly increasing the rate of hypoglycemia