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Heart failure disturbs gut-blood barrier and increases plasma trimethylamine, a toxic bacterial metabolite

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Assessment of consistency across finngen, PGC, UKB, and other GWAS datasets with meta-analysis To evaluate the consistency of our findings across multiple independent datasets, we conducted Mendelian randomization (MR) analyses using summary genetic data from the FinnGen consortium (R9) ( Psychiatric Genomics Consortium (PGC, and UK Biobank ( The number of individuals included in these analyses ranged from 133,164 to 306,119, as detailed in Supplementary Table S2