Under hyperglycemic conditions, dysfunction of the mitochondrial electron transport chain (ETC.) leads to excessive ROS production, subsequently inducing oxidative damage, mitochondrial DNA (mtDNA) mutations/leakage, and activation of inflammatory pathways such as the NLR family pyrin domain containing 3 (NLRP3) inflammasome and the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING), thereby exacerbating local and systemic inflammation and hindering wound healing (Wang et al., 2025a
I was just, like, totally shocked, he said
Analysis of oxidative stress-induced protein carbonylation using fluorescent hydrazides
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The emerging role of glutathione in Alzheimer's disease