Additionally, NAD serves as a substrate for sirtuins, a family of proteins that influence gene expression, DNA repair, and metabolic processes
Thus, we set out to determine, first, whether Kat6a +/ mice could be used as a model for ARTHS with respect to effects on histone acetylation and cognitive and social functions and, second, whether treatment aimed to increase histone acetylation levels might ameliorate any learning, memory, or social dysfunction that might be present
Further, the authors conclude timing of vitamin C administration in relation to aspirin administration is important
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