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It is not classified as a controlled substance under the Misuse of Drugs Act 1971, but it is also not approved as a medicine or food supplement
(PubMed) Essen A, Santaolalla A, Garmo H, et al
Wu QJ, Zhang TN, Chen HH, Yu XF, Lv JL, Liu YY, et al
Karnaukhova E, Krupnikova SS, Rajabi M, Alayash AI
Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss
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