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In the SELECT trial (among others), it showed lower rates of major adverse cardiovascular events (such as heart attacks and strokes) compared to placebo, especially in overweight or obese patients
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Also in kidney, localization of GLP-1 receptor is under investigation, but it is thought to be expressed in vascular smooth muscle cells and immune cells in kidney [43]
Most strikingly, multiple trials have now shown that GLP-1 agonists can lead to the resolution of MASH, a severe form of fatty liver disease, without worsening of liver fibrosis, which is a common adverse outcome seen with some current medications
Depression Vitamin B12 is necessary for the proper functioning of the brain
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