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Much evidence suggests that activation of anorexogenic proopiomelanocortin (POMC) neurons and simultaneous inhibition of orexigenic neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons in the ARC appears to be one of the major mechanisms for GLP-1R mediated inhibition of food intake

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World J Biol Chem 8(1):86

The presence of other substances can influence the outcomes of L-carnitine, making it difficult to assess its role in isolation