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Another proposed mechanism involves the binding of homocysteine to the collagenous matrix of bone, which may modify collagen properties and reduce bone strength (reviewed in 113)

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"We simply do not have the human data to make confident recommendations about BPC-157 for GI healing," noted a 2022 editorial in Peptides reviewing the state of the field

It can make it harder to know which compound is helping, which one is causing side effects, and how the overall protocol should be adjusted