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A compounded drug is made when a pharmacy unconnected with the manufacturer of a brand-name product formulates a custom-made version of a drug

10.1016/j.chemosphere.2010.10.070 Chemosphere 68 ReymondP.WeberH.DamondM.FarmerE

They are compounded by licensed 503A pharmacies with physician oversight and sterile quality standards, prioritizing real therapeutic outcomes over cheaper, unregulated research-grade products

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Impurities and degradation products alter receptor binding profiles, increasing off-target effects and reducing melanogenic efficacy