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Nature , 432 (7016), 466472

AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

B12 absorption occurs primarily through an intrinsic factor-dependent mechanism in the terminal ileum

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Conditions with acute or episodic or relapsing-remitting courses are less likely to be confused with vitamin B12 deficiency myelopathy (eg, trauma, multiple sclerosis), as are myelopathies resulting from intramedullary lesions or extramedullary compression