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Biomolecules 13(5):799 Manzanares W, Biestro A, Torre MH, Galusso F, Facchin G, Hardy G (2011) High-dose selenium reduces ventilator-associated pneumonia and illness severity in critically ill patients with systemic inflammation

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Because melanin synthesis is regulated by estrogen, dropping estrogen levels post-menopause are thought to be the primary triggers of age spots in women

Still, you should limit the amount you take to the daily dose on the supplement label, as there could be safety concerns with high doses of chanca piedra that havent been studied yet

Always consult a healthcare provider before exceeding this