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Dent R, McPherson R, Harper ME
The Phase 2 dose-finding trial (N=338), published in the New England Journal of Medicine in 2023 (DOI: 10.1056/NEJMoa2301972), randomized participants with obesity (BMI 30-50) to retatrutide at doses ranging from 0.5mg to 12mg weekly or placebo over 48 weeks
Lose weight quickly and that volume can deplete, leaving under-eye hollows, deeper tear troughs, and a more tired or sunken look even when you feel well
These solid wax blocks were cut into 5-m thick continuous section blocks in each section by a rotary microtome (Leica RM2125)
Nothing locks you in for the long haul: cancel future refills whenever you want, and you're never on the hook for more than the medication you've already paid for
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