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This is not a blunt-force genomic intervention
On its own its effects are modest, but combined with GLP-1 the two create a synergistic effect that amplifies both glycemic control and fat reduction beyond what either achieves alone which is why tirzepatide generally outperforms semaglutide in head-to-head comparisons
Vestlund J, Jerlhag E
The harder truth is that GLP-1s are a powerful tool, not a standalone solution without sustained lifestyle change, results are short-lived, and dropout rates climb
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