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Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers

Biomater Res 29:0138 Liu B, Liu Z, Lu X, Wu P, Sun Z, Chu H et al (2023) Controllable growth of drug-encapsulated metal-organic framework (MOF) on porphyrinic MOF for PDT/chemo-combined therapy

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When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells