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Of note, the commercial Iscoves Modified Dulbeccos Medium (IMDM) and Serum Free Expansion Medium (SFEM), which were used as the basal medium for erythroblast cultures, contain a supraphysiological concentration of cystine at 292 M as compared to physiological plasma concentration of 4075 M cysteine in SCD patients, which decreased further to 3060 M during vaso-occlusive pain episodes 36
Medically Reviewed by a UK Superintendent Pharmacist This content has been medically reviewed by Mohammed Ismail Lakhi (GPhC: 2072815) , Superintendent Pharmacist at The Care Pharmacy
Fitzgerald LM, Fryer JL, Dwyer T, Humphrey SM (Feb 2006)
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